Chelsea Handler Where:Caesars Palace Cost: $49.50 and up When: 10:30 p.m. Nov. 14 Info: (800) 745-3000

Familiar to third-shift workers, insomniacs and anyone kept awake at night by a newborn baby, Chelsea Handler is the one-woman wrecking crew best known for skewering Hollywood's misfits on Chelsea Lately.

Success hasn't always come easy to women who deign to venture past primetime. Ever since Joan Rivers left the late-night chair in the mid-'80s, the only women making waves past 11 p.m. have been in 900-number ads. But Handler is one plucky duck. Like Rivers, she's a steamroller: a savage satirist who's uncompromising in her attacks on everyone from Paris Hilton to Tori Spelling, and it's helped her become a staple in a male-dominated time slot.

Born in Livingston, N.J., Handler first gained fame on umpteen numbers of clip shows, where her snarky asides were used to great effect. Where would she be without 30 Most Outrageous Celebrity Feuds or 101 Incredible Celebrity Slimdowns? Moreover, where would we be?

Along the way, she's become one of the most popular female comics on the circuit today and, most unlikely, a gay icon. "I'm like a gay man trapped in a woman's body," Handler told The Advocate in January. She attributes her success in the gay community to a shared attitude of openness, a need to speak aloud the thoughts many would keep to themselves. Handler, too, admits to being an outcast as growing up, so it's no surprise that she takes great pride (gay, or otherwise) in having the last laugh.